| First Author | Yoshida K | Year | 2018 |
| Journal | Proc Natl Acad Sci U S A | Volume | 115 |
| Issue | 40 | Pages | E9459-E9468 |
| PubMed ID | 30224462 | Mgi Jnum | J:266651 |
| Mgi Id | MGI:6201647 | Doi | 10.1073/pnas.1806486115 |
| Citation | Yoshida K, et al. (2018) Leak potassium channels regulate sleep duration. Proc Natl Acad Sci U S A 115(40):E9459-E9468 |
| abstractText | A primary goal of sleep research is to understand the molecular basis of sleep. Although some sleep/wake-promoting circuits and secreted substances have been identified, the detailed molecular mechanisms underlying the regulation of sleep duration have been elusive. Here, to address these mechanisms, we developed a simple computational model of a cortical neuron with five channels and a pump, which recapitulates the cortical electrophysiological characteristics of slow-wave sleep (SWS) and wakefulness. Comprehensive bifurcation and detailed mathematical analyses predicted that leak K(+) channels play a role in generating the electrophysiological characteristics of SWS, leading to a hypothesis that leak K(+) channels play a role in the regulation of sleep duration. To test this hypothesis experimentally, we comprehensively generated and analyzed 14 KO mice, and found that impairment of the leak K(+) channel (Kcnk9) decreased sleep duration. Based on these results, we hypothesize that leak K(+) channels regulate sleep duration in mammals. |
