| First Author | Zhao JH | Year | 1998 |
| Journal | Oncogene | Volume | 17 |
| Issue | 8 | Pages | 1009-17 |
| PubMed ID | 9747880 | Mgi Jnum | J:52663 |
| Mgi Id | MGI:1329950 | Doi | 10.1038/sj.onc.1202026 |
| Citation | Zhao JH, et al. (1998) Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression. Oncogene 17(8):1009-17 |
| abstractText | We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protein during murine erythroleukemia (MEL) cell differentiation. In the present work, we demonstrated that YY-1 and c-Myc, a nuclear oncoprotein, were physically associated in vivo and that down regulation of c-Myc liberated free YY-1 from its complex, resulting in the functional binding of YY-1 to the Gp-LCR. We also showed that the E- box binding protein (EBP) which bound to E-box was physically associated with YY-1, facilitated binding of YY-1 to the neighboring site and their combinatorial binding may stimulate the GpLCR mediated enhancement of erythroid-specific transcription of glycophorin gene in MEL cells. |
