| First Author | Black HS | Year | 1998 |
| Journal | J Photochem Photobiol B | Volume | 44 |
| Issue | 2 | Pages | 124-9 |
| PubMed ID | 9757594 | Mgi Jnum | J:52683 |
| Mgi Id | MGI:1329980 | Doi | 10.1016/S1011-1344(98)00131-6 |
| Citation | Black HS, et al. (1998) Immunobiology of lipid-modulated UV-carcinogenesis. J Photochem Photobiol B 44(2):124-9 |
| abstractText | Previous studies have demonstrated that high levels of dietary fat exacerbate UV-carcinogenic expression and suppress immunoresponsiveness. The latter may account for the former response. We have explored this possibility through T-lymphocyte transfer studies. Groups of HRA.HRII-c/+/Skh hairless mice were fed isocaloric diets containing high (12%, wt./wt.) or low (0.75%) levels of corn oil and irradiated 5 days/week (1.0 J cm-2/day) for 11 weeks with filtered FS-40 sunlamps. At weeks nine and 12, enriched T-cells from high-fat donors that had received 11 weeks of UV were trans-ferred intravenously to low-fat recipients. Median tumor times for high-fat, low-fat recipient, and low-fat groups were 15.8, 18.5, and 21.6 weeks, respectively. The significantly (P < 0.03) shortened primary tumor latent period in low-fat-fed animals resulting from transfer of relatively low levels of T-cells derived from chronically irradiated high-fat donors demonstrates that the influence of dietary fat upon UV-carcinogenic expression is, at least partially, mediated via immunologic mechanisms. Further studies suggest that fat-modulated carcinogenesis can, itself, be regulated immunologically. A soluble T-14 (mouse squamous carcinoma cell line) cell-free fraction was injected subcutaneously at axillae and inguen of animals fed the high-fat diet during the first three weeks of UV or immediately post-UV. At week four post-UV, animals were challenged with T-14 cells injected subcutaneously at both flanks. 21 days post-challenge the tumor volumes of low-fat and high-fat immunized animals were zero versus 593 mm3 for the high-fat group (P < 0.007). Such treatment significantly (P < 0.03) increases the latent period of UV-induced primary tumors as well, when compared to non-treated high-fat-fed animals. |
