| First Author | Sakai K | Year | 1998 |
| Journal | Gene | Volume | 219 |
| Issue | 1-2 | Pages | 125-30 |
| PubMed ID | 9757017 | Mgi Jnum | J:50474 |
| Mgi Id | MGI:1306723 | Doi | 10.1016/s0378-1119(98)00322-9 |
| Citation | Sakai K, et al. (1998) The genomic organization of the human corticotropin-releasing factor type-1 receptor. Gene 219(1-2):125-30 |
| abstractText | We determined the genomic organization of human CRF type-1 receptor (hCRF-R1). The gene coding for hCRF-R1 consists of at least 14 exons and spans over 20 kilobases. hCRF-R1's three reported isoforms originate from the same gene by alternative splicing. The first hCRF-R1, which binds to CRF with the highest affinity and transduces the most sensitive cAMP accumulation in response to CRF, is encoded in a total of 13 exons, the only one excluded being exon 6. The second isoform contains an additional 29-amino acid sequence which corresponds to exon 6. Unlike the first isoform, the third lacks a 40-amino acid sequence, corresponding to exon 3. Exon-intron boundaries are the same as that of the consensus sequence. Locations of introns in the coding sequence are similar to human CRF-R1, rat CRF-R1, human CRF-R2alpha and others belonging to the human glucagon receptor family. |
