| First Author | Galland F | Year | 1998 |
| Journal | Genomics | Volume | 53 |
| Issue | 2 | Pages | 203-13 |
| PubMed ID | 9790769 | Mgi Jnum | J:50599 |
| Mgi Id | MGI:1306989 | Doi | 10.1006/geno.1998.5481 |
| Citation | Galland F, et al. (1998) Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. Genomics 53(2):203-13 |
| abstractText | We report here the identification of two distinct human cDNAs, called VNN1 and VNN2, related to the recently described mouse Vanin-1 molecule involved in lymphocyte migration (M. Aurrand-Lions et al., 1996, Immunity 5: 391-405). Tissue distribution of the expression of these two human Vanin-like genes is differential. Since Vanin-1 shares significant homologies with human biotinidase (BTD), we describe here a new family of related genes including at least four members: mouse Vanin-1, VNN1, VNN2, and BTD. We have mapped the murine locus encompassing the Vanin-1 gene on mouse chromosome 10 in position A2B1. The two human Vanin-like genes are closely linked, since they were found on the same YAC clone and colocalized on human chromo- some 6q23-q24 known to contain several genetic alterations linked to the progression of metastatic human cancers. Copyright 1998 Academic Press. |
