| First Author | Akagi A | Year | 1998 |
| Journal | Food Chem Toxicol | Volume | 36 |
| Issue | 12 | Pages | 1065-71 |
| PubMed ID | 9862648 | Mgi Jnum | J:52113 |
| Mgi Id | MGI:1328464 | Doi | 10.1016/s0278-6915(98)00077-5 |
| Citation | Akagi A, et al. (1998) Non-carcinogenicity of capsaicinoids in B6C3F1 mice. Food Chem Toxicol 36(12):1065-71 |
| abstractText | The carcinogenicity of a mixture of capsaicinoids (64.5% capsaicin and 32.6% dihydro-capsaicin) was examined in B6C3F1 mice. In a 13-week toxicity study, renal toxicity was observed in 1% capsaicinoid-treated males. Next, groups of 50 mice of each sex were given 0, 0.025, 0.083 or 0.25% capsaicinoids in powdered diet for 79 weeks and killed in week 83. Food intake was reduced in mice of all capsaicinoid-treated groups, especially females, because of the pungency of capsaicinoids, and inhibition of body weight gain was apparent in females. The numbers of tumour-bearing females in the high-dose groups were significantly lower than that in the controls, and the incidences of hepatocellular neoplasms in both sexes were negatively correlated with the dose of capsaicinoids (Cochran-Armitage trend test). Renal cell adenomas developed in one mouse each of 0.025 and 0.25% capsaicinoid-treated males. The incidences of other tumours were similar in the treated and control groups. Thus, the present study indicated that a mixture of capsaicinoids is not carcinogenic in B6C3F1 mice. |
