| First Author | Royet J | Year | 1998 |
| Journal | EMBO J | Volume | 17 |
| Issue | 24 | Pages | 7351-60 |
| PubMed ID | 9857191 | Mgi Jnum | J:51831 |
| Mgi Id | MGI:1327011 | Doi | 10.1093/emboj/17.24.7351 |
| Citation | Royet J, et al. (1998) Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity. EMBO J 17(24):7351-60 |
| abstractText | Signaling by Notch family receptors is involved in many cell-fate decisions during development. Several modifiers of Notch activity have been identified, suggesting that regulation of Notch signaling is complex. In a genetic screen for modifiers of Notch activity, we identified a gene encoding a novel WD40-repeat protein. The gene is called Notchless, because loss-of-function mutant alleles dominantly suppress the wing notching caused by certain Notch alleles. Reducing Notchless activity increases Notch activity. Overexpression of Notchless in Xenopus or Drosophila appears to have a dominant-negative effect in that it also increases Notch activity. Biochemical studies show that Notchless binds to the cytoplasmic domain of Notch, suggesting that it serves as a direct regulator of Notch signaling activity. |
