| First Author | Parker KL | Year | 1998 |
| Journal | Mol Cell Endocrinol | Volume | 145 |
| Issue | 1-2 | Pages | 15-20 |
| PubMed ID | 9922094 | Mgi Jnum | J:52346 |
| Mgi Id | MGI:1328887 | Doi | 10.1016/s0303-7207(98)00164-6 |
| Citation | Parker KL (1998) The roles of steroidogenic factor 1 in endocrine development and function. Mol Cell Endocrinol 145(1-2):15-20 |
| abstractText | The orphan nuclear receptor steroidogenic factor 1 (SF-1) was initially isolated as a key regulator of the cytochrome P450 steroid hydroxylases in adrenocortical and gonadal cells. Subsequent analyses of SF-1 knockout mice have expanded considerably our understanding of the roles that SF-1 plays in endocrine development. These SF-1 knockout mice lacked adrenal glands and gonads, with consequent male-to-female sex reversal of their internal and external genitalia. Thus, SF-1 is essential for the embryonic survival of the primary steroidogenic organs. They further exhibited impaired gonadotrope function and agenesis of the ventromedial hypothalamic nucleus, establishing that SF-1 contributes to reproductive function at all three levels of the hypothalamic-pituitary-gonadal axis. This report reviews experiments that have defined these critical roles of SF-1 in endocrine development, and highlights areas of ongoing investigation. |
