| First Author | Ralston E | Year | 1999 |
| Journal | Exp Cell Res | Volume | 246 |
| Issue | 2 | Pages | 510-5 |
| PubMed ID | 9925767 | Mgi Jnum | J:52447 |
| Mgi Id | MGI:1329299 | Doi | 10.1006/excr.1998.4305 |
| Citation | Ralston E, et al. (1999) Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers. Exp Cell Res 246(2):510-5 |
| abstractText | Caveolae are abundant in skeletal muscle and their coat contains a specific isoform of caveolin, caveolin-3. It has been suggested that during muscle development, caveolin-3 is associated with the T-tubules, but that in adult muscle it is found on the plasma membrane only. We have studied the distribution of caveolin-3 in single skeletal muscle fibers from adult rat soleus by confocal immunofluorescence and by immunogold electron microscopy. We found that caveolin-3 occurs at the highest density on the plasma membrane but is also present in the core of the fibers, at the I-band/A-band interface where it is associated with the T-tubules. In neither domain of the muscle surface does caveolin-3 colocalize with the glucose transporter GLUT4 and there is no evidence for internalization of the caveolae in muscle. Copyright 1999 Academic Press. |
