| First Author | Jensen PJ | Year | 1999 |
| Journal | J Invest Dermatol | Volume | 112 |
| Issue | 2 | Pages | 240-4 |
| PubMed ID | 9989802 | Mgi Jnum | J:52406 |
| Mgi Id | MGI:1329252 | Doi | 10.1046/j.1523-1747.1999.00494.x |
| Citation | Jensen PJ, et al. (1999) Urokinase is a positive regulator of epidermal proliferation in vivo. J Invest Dermatol 112(2):240-4 |
| abstractText | The epidermis is a self-renewing tissue that must maintain a basal proliferative rate as well as respond to various perturbing stimuli. Regulation of keratinocyte proliferation involves diverse molecules, including growth factors, ions, and hormones. We recently proposed that a proteinase, urokinase-type plasminogen activator (uPA) may be added to this list, based on correlative evidence linking expression of uPA and murine epidermal hyperproliferation. Here we report that, during the first 3 d of life, the epidermis from mice that bear a targeted deletion of the uPA gene has a significantly lower proliferative rate than the epidermis from wild-type mice. In contrast, proliferation in the matrix keratinocytes of the hair follicles is not decreased in neonatal uPA-/- mice. Vertical migration of keratinocytes during terminal differentiation was not affected. We therefore conclude that lack of uPA is associated with a decrease in epidermal proliferation. |
