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Publication : The Toll-receptor family and control of innate immunity.

First Author  Kopp EB Year  1999
Journal  Curr Opin Immunol Volume  11
Issue  1 Pages  13-8
PubMed ID  10047546 Mgi Jnum  J:53152
Mgi Id  MGI:1331337 Doi  10.1016/s0952-7915(99)80003-x
Citation  Kopp EB, et al. (1999) The Toll-receptor family and control of innate immunity. Curr Opin Immunol 11(1):13-8
abstractText  Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants.
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