First Author | Kopp EB | Year | 1999 |
Journal | Curr Opin Immunol | Volume | 11 |
Issue | 1 | Pages | 13-8 |
PubMed ID | 10047546 | Mgi Jnum | J:53152 |
Mgi Id | MGI:1331337 | Doi | 10.1016/s0952-7915(99)80003-x |
Citation | Kopp EB, et al. (1999) The Toll-receptor family and control of innate immunity. Curr Opin Immunol 11(1):13-8 |
abstractText | Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants. |