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Publication : C1q-binding proteins and C1q receptors.

First Author  Nicholson-Weller A Year  1999
Journal  Curr Opin Immunol Volume  11
Issue  1 Pages  42-6
PubMed ID  10047536 Mgi Jnum  J:53148
Mgi Id  MGI:1331333 Doi  10.1016/s0952-7915(99)80008-9
Citation  Nicholson-Weller A, et al. (1999) C1q-binding proteins and C1q receptors. Curr Opin Immunol 11(1):42-6
abstractText  Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease. The search for the C1q receptor(s), which has been ongoing for 25 years, has led recently to the recognition that proteins identified as binding to C1q may be divided into two groups: C1q-binding molecules that are normally intracellular; and cell surface C1q receptors.
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