| First Author | Früh K | Year | 1999 |
| Journal | Curr Opin Immunol | Volume | 11 |
| Issue | 1 | Pages | 76-81 |
| PubMed ID | 10047537 | Mgi Jnum | J:53146 |
| Mgi Id | MGI:1331331 | Doi | 10.1016/s0952-7915(99)80014-4 |
| Citation | Fruh K, et al. (1999) Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol 11(1):76-81 |
| abstractText | Antigen processing by MHC class I molecules begins with the generation of peptides by proteolytic breakdown of proteins. IFN-gamma upregulates gene expression of several proteasomal subunits as well as the proteasome regulator PA28; this implicated their role in antigen degradation. Crystallographic, mutational and biochemical studies contributed to our understanding of the basic principles of proteasomal protein degradation and the consequences of IFN-gamma induction for proteasome function. In addition, nonproteasomal mechanisms seem to be involved in antigen degradation. Leucine aminopeptidase, which is also upregulated by IFN-gamma, was shown to collaborate with the proteasome for epitope production and unknown proteases seem to compensate for the loss of proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather complex picture emerges for the rules governing peptide production in the presence or absence of IFN-gamma. |
