| First Author | Hornum L | Year | 1999 |
| Journal | Mamm Genome | Volume | 10 |
| Issue | 3 | Pages | 244-8 |
| PubMed ID | 10051319 | Mgi Jnum | J:53816 |
| Mgi Id | MGI:1333441 | Doi | 10.1007/s003359900981 |
| Citation | Hornum L, et al. (1999) Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia. Mamm Genome 10(3):244-8 |
| abstractText | Caspase-2 is a member of the caspase family of cystein proteases involved in programmed cell death or apoptosis. Functional and genetic data suggest it as a candidate gene for lymphopenia (Lyp)-a susceptibility gene for rat diabetes-which is responsible for the T-cell lymphopenia in the diabetes-prone BB rat. Firstly, there is a higher frequency of apoptosis among recent thymic emigrants in the diabetes-prone BB rat than in the non-lymphopenic diabetes-resistant BB rat. Secondly, caspase-2 maps close to Tcrb on mouse Chromosome (Chr) 6, while Lyp is closely linked to Tcrb on the homologous rat Chr 4. In this paper, we report genetic fine-positioning and radiation hybrid mapping of caspase-2 in the rat. Both methods positioned caspase-2 to rat Chr 4 between markers Prss1 and D4Mit5. Since Lyp maps distally to D4Mit5, between markers D4Rat75 and Npy, we exclude caspase-2 as a candidate gene for Lyp. |
