| First Author | Busetti A | Year | 1999 |
| Journal | Br J Cancer | Volume | 79 |
| Issue | 5-6 | Pages | 821-4 |
| PubMed ID | 10070875 | Mgi Jnum | J:53732 |
| Mgi Id | MGI:1333350 | Doi | 10.1038/sj.bjc.6690131 |
| Citation | Busetti A, et al. (1999) High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma. Br J Cancer 79(5-6):821-4 |
| abstractText | Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 micromol kg(-1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 micromol kg(-1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes. |
