| First Author | Mai M | Year | 1999 |
| Journal | Genomics | Volume | 55 |
| Issue | 3 | Pages | 341-4 |
| PubMed ID | 10049590 | Mgi Jnum | J:53208 |
| Mgi Id | MGI:1331518 | Doi | 10.1006/geno.1998.5650 |
| Citation | Mai M, et al. (1999) Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. Genomics 55(3):341-4 |
| abstractText | Conductin or Axil, an Axin homolog, plays an important role in the regulation of beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3beta (96.3%), Dsh (98%), and beta-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types. |
