| First Author | Murdoch JN | Year | 1999 |
| Journal | Dev Genet | Volume | 24 |
| Issue | 1-2 | Pages | 165-77 |
| PubMed ID | 10079519 | Mgi Jnum | J:53409 |
| Mgi Id | MGI:1332391 | Doi | 10.1002/(SICI)1520-6408(1999)24:1/2<165::AID-DVG15>3.0.CO;2-V |
| Citation | Murdoch JN, et al. (1999) Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis. Dev Genet 24(1-2):165-77 |
| abstractText | Nhlh1 is a basic helix-loop-helix (bHLH) gene thai has been implicated in mouse neurogenesis. Previous studies have shown it to be expressed in regions in which there are differentiating neurons during late embryonic and fetal development, but detailed studies of the role of Nhlh 1 earlier in embryonic development have not been performed, in this paper, we examine the expression of Nhlh I transcripts ai early embryonic stages (E8.5-E10.5), at the onset of neurogenesis, and compare the pattern of expression with that of Islet-1, a marker of postmitotic neurons. We show that Nhlh I is expressed in early postmitotic neurons but is down-regulated as these cells migrate from the ventricular zone. We have also determined the genomic structure of mouse Nhlh I and have characterised the promoter sequence, as a first step towards identifying factors that may control Nhlh 1 expression. Nhlh I has been implicated previously as a candidate for the neural tube defect mutant loop-tail (Lp); here, we present sequence and expression data indicating that Nhlh I is unlikely to be responsible for the ip mutation. (C) 1999 Wiley-Liss, Inc. |
