| First Author | Hinz M | Year | 1999 |
| Journal | Mol Cell Biol | Volume | 19 |
| Issue | 4 | Pages | 2690-8 |
| PubMed ID | 10082535 | Mgi Jnum | J:54291 |
| Mgi Id | MGI:1334892 | Doi | 10.1128/mcb.19.4.2690 |
| Citation | Hinz M, et al. (1999) NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19(4):2690-8 |
| abstractText | Nuclear factor kappa B (NF-kappa B) has been implicated in the regulation of cell proliferation, transformation, and tumor development. We proc ide evidence for a direct link between NF-kappa B activity and cell cycle regulation. NF- kappa B was found to stimulate transcription of cyclin D1, a key regulator of G(1) checkpoint control. Two NF-kappa B binding sites in the human cyclin D1 promoter conferred activation by NF-kappa B as well as by growth factors. Both levels and kinetics of cyclin D1 expression during G(1) phase were controlled by NF-kappa B. Moreover, inhibition of NF-kappa B caused a pronounced reduction of serum-induced cyclin D1-associated kinase activity and resulted in delayed phosphorylation of the retinoblastoma protein. Furthermore, NF-kappa B promotes G(1)-to-S-phase transition in mouse embryonal fibroblasts and in T47D mammary carcinoma cells. Impaired cell cycle progression of T47D cells expressing an NF-kappa B superrepressor (I kappa B alpha Delta N) could be rescued by ectopic expression of cyclin D1, Thus, NF-kappa B contributes to cell cycle progression, and one of its targets might be cyclin D1. |
