| First Author | Puthalakath H | Year | 1999 |
| Journal | Mol Cell | Volume | 3 |
| Issue | 3 | Pages | 287-96 |
| PubMed ID | 10198631 | Mgi Jnum | J:54014 |
| Mgi Id | MGI:1334003 | Doi | 10.1016/s1097-2765(00)80456-6 |
| Citation | Puthalakath H, et al. (1999) The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3(3):287-96 |
| abstractText | Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to the microtubule-associated dynein motor complex. Certain apoptotic stimuli disrupted the interaction between LC8 and the dynein motor complex. This freed Bim to translocate together with LC8 to Bcl-2 and to neutralize its antiapoptotic activity. This process did not require caspase activity and therefore constitutes an initiating event in apoptosis signaling. |
