| First Author | Zhou X | Year | 1999 |
| Journal | J Immunol | Volume | 162 |
| Issue | 7 | Pages | 3957-60 |
| PubMed ID | 10201915 | Mgi Jnum | J:53573 |
| Mgi Id | MGI:1332946 | Doi | 10.4049/jimmunol.162.7.3957 |
| Citation | Zhou X, et al. (1999) Increased generation of CD8+ T cell clones in p53 mutant mice. J Immunol 162(7):3957-60 |
| abstractText | Very few cultured CD8+ T cell clones can normally be obtained from a single mouse and maintained in long-term culture. To improve the yield, we immunized p53 mutant mice with peptides of Sendai virus (FAPGNYPAL) and influenza virus (ASNENMETM) origin. Substantially more clones could be derived from p53-/- mice than from similarly treated wild-type mice (p53+/+); an intermediate yield was obtained from heterozygous mice (p53+/-). CTL lines or clones from p53-/- mice exhibited greater proliferative activity and resistance to gamma-irradiation than those from p53+/+ mice, and were cytolytically potent. |
