| First Author | Maehama T | Year | 1999 |
| Journal | Trends Cell Biol | Volume | 9 |
| Issue | 4 | Pages | 125-8 |
| PubMed ID | 10203785 | Mgi Jnum | J:54104 |
| Mgi Id | MGI:1334102 | Doi | 10.1016/s0962-8924(99)01519-6 |
| Citation | Maehama T, et al. (1999) PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9(4):125-8 |
| abstractText | The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, including phosphatidylinositol (3,4,5)-trisphosphate, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signalling. This article discusses the function of PTEN and how this could be linked to its activity as a tumour suppressor. |
