| First Author | Nawrath M | Year | 1999 |
| Journal | Leukemia | Volume | 13 Suppl 1 |
| Pages | S48-51 | PubMed ID | 10232365 |
| Mgi Jnum | J:55340 | Mgi Id | MGI:1337732 |
| Doi | 10.1038/sj.leu.2401284 | Citation | Nawrath M, et al. (1999) Reduced melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen gp100/pmel17. Leukemia 13 Suppl 1:S48-51 |
| abstractText | Plasmid DNA encoding gene products of viruses or other pathogens has recently been applied by intramuscular injection as a novel type of vaccine. It can induce cytotoxic T cell response in small animals and protect against challenge with influenza A viruses. Combinations with cytokines or DNA-encoding cytokines have been applied in order to increase the efficiency of protection. A DNA vaccine has been analyzed here against malignant melanoma encoding gp100/pmel17, a melanoma-associated antigen. A small animal model was used by injection of B16 melanoma cells to syngeneic C57Bl/6 mice. DNA vaccination before tumor cell challenge leads to about 50% reduction of tumor size. The cytokine gene coding for GM-CSF did not increase the efficiency but also led to tumor size reduction when applied alone. |
