| First Author | Kurosaki T | Year | 1999 |
| Journal | Annu Rev Immunol | Volume | 17 |
| Pages | 555-92 | PubMed ID | 10358768 |
| Mgi Jnum | J:55440 | Mgi Id | MGI:1338126 |
| Doi | 10.1146/annurev.immunol.17.1.555 | Citation | Kurosaki T (1999) Genetic analysis of B cell antigen receptor signaling. Annu Rev Immunol 17:555-92 |
| abstractText | In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future. |
