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Publication : The roles of RNA-binding proteins in spermatogenesis and male infertility.

First Author  Venables JP Year  1999
Journal  Curr Opin Genet Dev Volume  9
Issue  3 Pages  346-54
PubMed ID  10377282 Mgi Jnum  J:55872
Mgi Id  MGI:1339506 Doi  10.1016/s0959-437x(99)80052-5
Citation  Venables JP, et al. (1999) The roles of RNA-binding proteins in spermatogenesis and male infertility. Curr Opin Genet Dev 9(3):346-54
abstractText  RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.
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