| First Author | Davies J | Year | 1999 |
| Journal | Oncogene | Volume | 18 |
| Issue | 24 | Pages | 3643-7 |
| PubMed ID | 10380886 | Mgi Jnum | J:55885 |
| Mgi Id | MGI:1339519 | Doi | 10.1038/sj.onc.1202956 |
| Citation | Davies J, et al. (1999) Cooperation of Myb and Myc proteins in T cell lymphomagenesis. Oncogene 18(24):3643-7 |
| abstractText | The v-Myb oncogene causes late onset T cell lymphomas when expressed in the T cell lineage of transgenic mice. In order to define the cellular mutations cooperating with s-Myb to cause lymphomas, we have infected v-Myb transgenic mice with Moloney murine leukemia virus (M-MuLV). Tumor formation is significantly accelerated from a mean age of onset of 60 weeks in uninfected vMyb transgenics to 13 weeks in infected vMyb transgenics. We studied the loci into which the M-MuLV had inserted, and found that in 73% of animals, either the c-myc or the N-myc genes had been disrupted and deregulated. Therefore, v-myb and c-myb can cooperate to induce T cell lymphomas. |
