| First Author | Kaneko M | Year | 1999 |
| Journal | FEBS Lett | Volume | 452 |
| Issue | 3 | Pages | 237-42 |
| PubMed ID | 10386598 | Mgi Jnum | J:55655 |
| Mgi Id | MGI:1339175 | Doi | 10.1016/s0014-5793(99)00640-7 |
| Citation | Kaneko M, et al. (1999) Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. FEBS Lett 452(3):237-42 |
| abstractText | The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of nonsynonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the alpha-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution, The human Fuc-TIX (hFuc- TIX) showed a unique characteristics, i.e. HFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc- TVI were activated by the cations, The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes, (C) 1999 Federation of European Biochemical Societies. |
