| First Author | Tenenhouse HS | Year | 1999 |
| Journal | Curr Opin Nephrol Hypertens | Volume | 8 |
| Issue | 4 | Pages | 407-14 |
| PubMed ID | 10491734 | Mgi Jnum | J:59486 |
| Mgi Id | MGI:1351721 | Doi | 10.1097/00041552-199907000-00003 |
| Citation | Tenenhouse HS (1999) Recent advances in epithelial sodium-coupled phosphate transport [see comments]. Curr Opin Nephrol Hypertens 8(4):407-14 |
| abstractText | This review focuses on recent developments in the molecular characterization of renal sodium-phosphate cotransporters and the mechanisms involved in their regulation. Of the three classes of sodium-phosphate cotransporters expressed in the mammalian kidney, the type II transporter, NPT2/Npt2 reflects the characteristics of apical sodium-dependent phosphate transport, and is a target for regulation. Studies in mice in which the Npt2 gene was disrupted by targeted mutagenesis underscore the importance of Npt2 in the maintenance of phosphate homeostasis. Recent advances in our understanding of phosphate transport mechanisms in intestine and bone are also discussed. |
