| First Author | Barco A | Year | 2002 |
| Journal | Cell | Volume | 108 |
| Issue | 5 | Pages | 689-703 |
| PubMed ID | 11893339 | Mgi Jnum | J:75368 |
| Mgi Id | MGI:2176386 | Doi | 10.1016/s0092-8674(02)00657-8 |
| Citation | Barco A, et al. (2002) Expression of Constitutively Active CREB Protein Facilitates the Late Phase of Long-Term Potentiation by Enhancing Synaptic Capture. Cell 108(5):689-703 |
| abstractText | Restricted and regulated expression in mice of VP16-CREB, a constitutively active form of CREB, in hippocampal CA1 neurons lowers the threshold for eliciting a persistent late phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This L-LTP has unusual properties in that its induction is not dependent on transcription. Pharmacological and two-pathway experiments suggest a model in which VP16-CREB activates the transcription of CRE-driven genes and leads to a cell-wide distribution of proteins that prime the synapses for subsequent synapse-specific capture of L-LTP by a weak stimulus. Our analysis indicates that synaptic capture of CRE-driven gene products may be sufficient for consolidation of LTP and provides insight into the molecular mechanisms of synaptic tagging and synapse-specific potentiation. |
