| First Author | Kovacs CS | Year | 2002 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 282 |
| Issue | 3 | Pages | E721-32 |
| PubMed ID | 11832378 | Mgi Jnum | J:75520 |
| Mgi Id | MGI:2177001 | Doi | 10.1152/ajpendo.00369.2001 |
| Citation | Kovacs CS, et al. (2002) Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am J Physiol Endocrinol Metab 282(3):E721-32 |
| abstractText | The expression of calcitropic genes and proteins was localized within murine placenta during late gestation (the time frame of active calcium transfer) with an analysis of several gene-deletion mouse models by immunohistochemistry and in situ hybridization. Parathyroid hormone-related protein (PTHrP), the PTH/PTHrP receptor, calcium receptor, calbindin-D(9k), Ca(2+)-ATPase, and vitamin D receptor were all highly expressed in a localized structure of the murine placenta, the intraplacental yolk sac, compared with trophoblasts. In the PTHrP gene-deleted or Pthrp-null placenta in which placental calcium transfer is decreased, calbindin-D(9k) expression was downregulated in the intraplacental yolk sac but not in the trophoblasts. These observations indicated that the intraplacental yolk sac contains calcium transfer and calcium-sensing capability and that it is a probable route of maternal-fetal calcium exchange in the mouse. |
