| First Author | Seimiya M | Year | 2002 |
| Journal | Biochem Biophys Res Commun | Volume | 292 |
| Issue | 1 | Pages | 121-7 |
| PubMed ID | 11890681 | Mgi Jnum | J:75689 |
| Mgi Id | MGI:2177371 | Doi | 10.1006/bbrc.2002.6605 |
| Citation | Seimiya M, et al. (2002) Clast5/Stra13 is a negative regulator of B lymphocyte activation. Biochem Biophys Res Commun 292(1):121-7 |
| abstractText | CD40 is a member of the tumor necrosis factor receptor family and mediates a variety of functions of B cells, including B cell survival, proliferation, immunoglobulin gene class switching, memory B cell formation, and regulation of Fas-mediated apoptosis. To begin to elucidate the molecular mechanism governing such diverse functions of CD40, we have isolated a gene from mouse splenic B cells, termed Clast5, whose expression is strongly repressed during B cell activation. Clast5 is identical with Stra13, a recently identified member of the basic helix-loop-helix family of transcription factors. Clast5/Stra13 is highly expressed in unstimulated, resting B cells and is rapidly downregulated by a variety of stimuli that activate B cells, including CD40 ligand, anti-IgM antibodies, lipopolysaccharides and interleukin-4. Forced expression of Clast5/Stra13 in B cells delayed the cell cycle progression into S phase and strongly suppressed Fas-mediated apoptosis. Moreover, Clast5/Stra13 inhibited the colony formation in fibroblasts. Our results suggest that Clast5/Stra13 functions as a negative regulator of B cell activation by inhibiting cell cycle progression and cell growth. (C)2002 Elsevier Science (USA). |
