| First Author | Chakraborty A | Year | 2002 |
| Journal | Cancer Lett | Volume | 177 |
| Issue | 1 | Pages | 1-5 |
| PubMed ID | 11809524 | Mgi Jnum | J:74410 |
| Mgi Id | MGI:2158211 | Doi | 10.1016/s0304-3835(01)00766-2 |
| Citation | Chakraborty A, et al. (2002) Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Lett 177(1):1-5 |
| abstractText | Achyranthes aspera leaves have been assessed for chemopreventive activity. The MeOH extract, alkaloid, non-alkaloid and saponin fractions exhibited significant inhibitory effects (concentration 100 microg) on the Epstein-Barr virus early antigen activation induced by the tumor promotor 12-O-tetradecanoylphorbol-13-acetate in Raji cells. In this in vitro assay the non-alkaloid fraction containing mainly non-polar compounds showed the most significant inhibitory activity (96.9%; 60% viability). In the in vivo two-stage mouse skin carcinogenesis test the total methanolic extract possessed a pronounced anticarcinogenic effect (76%). The present study suggests that A. aspera leaf extract and the non-alkaloid fraction are valuable antitumor promotors in carcinogenesis. |
