| First Author | Jameson J | Year | 2002 |
| Journal | Science | Volume | 296 |
| Issue | 5568 | Pages | 747-9 |
| PubMed ID | 11976459 | Mgi Jnum | J:76250 |
| Mgi Id | MGI:2178908 | Doi | 10.1126/science.1069639 |
| Citation | Jameson J, et al. (2002) A role for skin gammadelta T cells in wound repair. Science 296(5568):747-9 |
| abstractText | Gammadelta T cell receptor-bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in gammadelta DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair. |
