| First Author | Barlow GM | Year | 2002 |
| Journal | Biochem Biophys Res Commun | Volume | 293 |
| Issue | 3 | Pages | 881-91 |
| PubMed ID | 12051741 | Mgi Jnum | J:76619 |
| Mgi Id | MGI:2179798 | Doi | 10.1016/S0006-291X(02)00307-8 |
| Citation | Barlow GM, et al. (2002) Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?. Biochem Biophys Res Commun 293(3):881-91 |
| abstractText | Central nervous system (CNS) development involves neural patterning, neuronal and axonal migrations, and synapse formation. DSCAM, a chromosome 21 axon guidance molecule, is expressed by CNS neurons during development and throughout adult life. We now report that DSCAM and its chromosome 11 paralog DSCAML1 exhibit inverse ventral-dorsal expression patterns in the developing spinal cord and distinct, partly inverse, expression patterns in the developing cortex, beginning in the Cajal-Retzius cells. In the adult cortex, DSCAM predominates in layer 3/5 pyramidal cells and DSCAML1 predominates in layer 2 granule cells. In the cerebellum, DSCAM is stronger in the Purkinje cells and DSCAML1 in the granule cells. Finally, we find that the predicted DSCAML1 protein contains 60 additional N-terminal amino acids which may contribute to its distinct expression pattern and putative function. We propose that the DSCAMs comprise novel elements of the pathways mediating dorsal-ventral patterning and cell-fate specification in the developing CNS. |
