| First Author | Chuvpilo S | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 6 | Pages | 881-95 |
| PubMed ID | 12121669 | Mgi Jnum | J:77525 |
| Mgi Id | MGI:2181925 | Doi | 10.1016/s1074-7613(02)00329-1 |
| Citation | Chuvpilo S, et al. (2002) Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis. Immunity 16(6):881-95 |
| abstractText | Threshold levels of individual NFAT factors appear to be critical for apoptosis induction in effector T cells. In these cells, the short isoform A of NFATc1 is induced to high levels due to the autoregulation of the NFATc1 promoter P1 by NFATs. P1 is located within a CpG island in front of exon 1, represents a DNase I hypersensitive chromatin site, and harbors several sites for binding of inducible transcription factors, including a tandemly arranged NFAT site. A second promoter, P2, before exon 2, is not controlled by NFATs and directs synthesis of the longer NFATc1/B+C isoforms. Contrary to other NFATs, NFATc1/A is unable to promote apoptosis, suggesting that NFATc1/A enhances effector functions without promoting apoptosis of effector T cells. |
