| First Author | Gu W | Year | 2002 |
| Journal | FEBS Lett | Volume | 519 |
| Issue | 1-3 | Pages | 71-6 |
| PubMed ID | 12023020 | Mgi Jnum | J:77120 |
| Mgi Id | MGI:2181072 | Doi | 10.1016/s0014-5793(02)02713-8 |
| Citation | Gu W, et al. (2002) The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. FEBS Lett 519(1-3):71-6 |
| abstractText | Recently mutations in the LGI1 (leucine-rich, glioma-inactivated 1) gene have been found in human temporal lobe epilepsy. We have now identified three formerly unknown LGI-like genes. Hydropathy plots and pattern analysis showed that LGI genes encode proteins with large extra- and intracellular domains connected by a single transmembrane region. Sequence analysis demonstrated that LGI1, LGI2, LGI3, and LGI4 form a distinct subfamily when compared to other leucine-rich repeat-containing proteins. In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis. |
