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Publication : IAP proteins: blocking the road to death's door.

First Author  Salvesen GS Year  2002
Journal  Nat Rev Mol Cell Biol Volume  3
Issue  6 Pages  401-10
PubMed ID  12042762 Mgi Jnum  J:77399
Mgi Id  MGI:2181533 Doi  10.1038/nrm830
Citation  Salvesen GS, et al. (2002) IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3(6):401-10
abstractText  The 'inhibitor of apoptosis' (IAP) gene family, which was discovered less than a decade ago, encodes a group of structurally related proteins that, in addition to their ability to suppress apoptotic cell death, are involved in an increasing number of seemingly unrelated cellular functions. Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function.
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