| First Author | Wang J | Year | 2002 |
| Journal | Biochim Biophys Acta | Volume | 1576 |
| Issue | 1-2 | Pages | 219-24 |
| PubMed ID | 12031506 | Mgi Jnum | J:77253 |
| Mgi Id | MGI:2181251 | Doi | 10.1016/s0167-4781(02)00340-8 |
| Citation | Wang J, et al. (2002) Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Biochim Biophys Acta 1576(1-2):219-24 |
| abstractText | Ribosomal protein (Rp) L6 is also defined as Taxreb107 (Tax responsive element binding protein 107) for its binding activity to the long terminal repeats of human T cell leukemia virus (HTLV)-I. We cloned the genomic gene of mouse RpL6/Taxreb107 and analyzed its exon/intron structures. The promoter of RpL6/Taxreb107 contains recognition sites for multiple transcription factors including nuclear factor (NF)-kappaB. Luciferase reporter assay showed that the RpL6/Taxreb107 promoter has a constitutive activity in transfected cells, and the constitutive activity depends on the intact promoter. Expression of HTLV-I viral protein Tax mildly but reproducibly induced RpL6/Taxreb107 mRNA and promoter activity. We provide evidence suggesting that induction of RpL6/Taxreb107 by Tax is at least partially mediated by the NF-kappaB site in the promoter of RpL6/Taxreb107. Taken together, Tax up-regulates RpL6/Taxreb107 and this may provide a feedback mechanism to facilitate proliferation of HTLV-I-infected cells and production of viral particles. |
