| First Author | Wilson ME | Year | 2002 |
| Journal | Mech Dev | Volume | 115 |
| Issue | 1-2 | Pages | 171-6 |
| PubMed ID | 12049785 | Mgi Jnum | J:77320 |
| Mgi Id | MGI:2181353 | Doi | 10.1016/s0925-4773(02)00118-1 |
| Citation | Wilson ME, et al. (2002) Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev 115(1-2):171-6 |
| abstractText | The earliest endocrine cells in the developing pancreas make glucagon and are described as alpha cells. We show here that these cells express islet amyloid polypeptide and prohormone convertase 1/3 (PC1/3), proteins that are not expressed by mature alpha cells, but are found in beta cells. PC1/3 converts proglucagon to the functionally distinct hormones glucagon-like peptide (GLP)-1 and GLP-2 rather than glucagon. Despite these differences, the early proglucagon-positive cells express, as do mature alpha cells, the POU domain transcription factor Brn-4, and do not express the beta cell factor pdx-1. The early production of atypical peptide hormones by these cells suggests that they could play an important role locally or systemically in the development of the embryo. |
