| First Author | Winter E | Year | 2002 |
| Journal | Trends Biochem Sci | Volume | 27 |
| Issue | 8 | Pages | 381-3 |
| PubMed ID | 12151215 | Mgi Jnum | J:78350 |
| Mgi Id | MGI:2384252 | Doi | 10.1016/s0968-0004(02)02154-0 |
| Citation | Winter E, et al. (2002) TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?. Trends Biochem Sci 27(8):381-3 |
| abstractText | A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum. |
