| First Author | Speiser DE | Year | 1997 |
| Journal | J Exp Med | Volume | 185 |
| Issue | 10 | Pages | 1777-83 |
| PubMed ID | 9151703 | Mgi Jnum | J:79301 |
| Mgi Id | MGI:2387754 | Doi | 10.1084/jem.185.10.1777 |
| Citation | Speiser DE, et al. (1997) A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. J Exp Med 185(10):1777-83 |
| abstractText | Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-kappaB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8(+) T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily. |
