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Publication : Differential Pax6 promoter activity and transcript expression during forebrain development.

First Author  Anderson TR Year  2002
Journal  Mech Dev Volume  114
Issue  1-2 Pages  171-5
PubMed ID  12175506 Mgi Jnum  J:76822
Mgi Id  MGI:2180400 Doi  10.1016/s0925-4773(02)00051-5
Citation  Anderson TR, et al. (2002) Differential Pax6 promoter activity and transcript expression during forebrain development. Mech Dev 114(1-2):171-5
abstractText  Three different Pax6 promoters -- P0, P1, and P alpha -- show differential activity in the developing eye and spinal cord. To examine promoter usage during forebrain development, we performed in situ hybridization and reverse transcription-polymerase chain reaction to detect transcripts initiated from each promoter. Promoter-specific transcripts are expressed within subdomains of total Pax6 expression, but differ from one another in their spatial localization and expression over time. Additionally, we identified a novel P0-initiated transcript and detected a developmentally regulated antisense transcript.
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