| First Author | Nahle Z | Year | 2002 |
| Journal | Nat Cell Biol | Volume | 4 |
| Issue | 11 | Pages | 859-64 |
| PubMed ID | 12389032 | Mgi Jnum | J:80566 |
| Mgi Id | MGI:2446359 | Doi | 10.1038/ncb868 |
| Citation | Nahle Z, et al. (2002) Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol 4(11):859-64 |
| abstractText | Unrestrained E2F activity forces S phase entry and promotes apoptosis through p53-dependent and -independent mechanisms. Here, we show that deregulation of E2F by adenovirus E1A, loss of Rb or enforced E2F-1 expression results in the accumulation of caspase proenzymes through a direct transcriptional mechanism. Increased caspase levels seem to potentiate cell death in the presence of p53-generated signals that trigger caspase activation. Our results demonstrate that mitogenic oncogenes engage a tumour suppressor network that functions at multiple levels to efficiently induce cell death. The data also underscore how cell cycle progression can be coupled to the apoptotic machinery. |
