| First Author | Dubruille R | Year | 2002 |
| Journal | Development | Volume | 129 |
| Issue | 23 | Pages | 5487-98 |
| PubMed ID | 12403718 | Mgi Jnum | J:80083 |
| Mgi Id | MGI:2429666 | Doi | 10.1242/dev.00148 |
| Citation | Dubruille R, et al. (2002) Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 129(23):5487-98 |
| abstractText | Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfx mutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila. |
