| First Author | Furuta T | Year | 2002 |
| Journal | Genesis | Volume | 34 |
| Issue | 4 | Pages | 244-50 |
| PubMed ID | 12434334 | Mgi Jnum | J:80694 |
| Mgi Id | MGI:2446947 | Doi | 10.1002/gene.10157 |
| Citation | Furuta T, et al. (2002) Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Genesis 34(4):244-50 |
| abstractText | Summary: Many kinases are required for progression through the eukaryotic cell cycle. The Aurora kinases comprise a highly conserved family of serine/threonine kinases that have been implicated in chromosome segregation and cytokinesis in several organisms. We have isolated a sterile Caenorhabditis elegans mutant in which the majority of the locus encoding the Aurora A kinase air-1 has been deleted. Complementation tests with previously isolated sterile mutations in the air-1 genetic interval demonstrate that the air-1 and let-412 loci are identical. Previous analysis of AIR-1 function by RNA-mediated interference (RNAi) has shown that AIR-1 is required for embryonic survival. The characterization of the three sterile air-1 mutant alleles described here extends these studies by revealing an allelic series that differentially affects postembryonic cell divisions and germline development. genesis 34:244-250, 2002. |
