| First Author | Wille JJ Jr | Year | 2003 |
| Journal | Cancer Lett | Volume | 190 |
| Issue | 2 | Pages | 143-9 |
| PubMed ID | 12565168 | Mgi Jnum | J:81531 |
| Mgi Id | MGI:2449506 | Doi | 10.1016/s0304-3835(02)00594-3 |
| Citation | Wille JJ (2003) Circadian rhythm of tumor promotion in the two-stage model of mouse tumorigenesis. Cancer Lett 190(2):143-9 |
| abstractText | The question of whether cancer risk is influenced by time-of-day exposure to potentially carcinogenic agents was approached in this study by exposing mouse skin to a single initiating dose of 7,12-dimethylbenz [ for all -]anthracene, followed by a 12 week regime of bi-weekly skin treatments with the tumor promoter, 12-0-tetradecanoyl-phorbol acetate (TPA), given at four different circadian clock times (CCTs). Tumor incidence, average number of tumors per mouse and tumor size showed a dominant circadian component with an acrophase occurring at 23:00 h CCT. Pre-treatment with all trans-retinoic acid, prior to bi-weekly TPA promotion, reduced tumor incidence, average number and size of tumors per animal by greater than 80%, but did not suppress the underlying circadian rhythm of sensitivity to TPA-induced tumor formation. |
