| First Author | Shimizu J | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 4 | Pages | 1675-82 |
| PubMed ID | 12574330 | Mgi Jnum | J:81803 |
| Mgi Id | MGI:2450025 | Doi | 10.4049/jimmunol.170.4.1675 |
| Citation | Shimizu J, et al. (2003) CD4(+)CD25(-) T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity. J Immunol 170(4):1675-82 |
| abstractText | Studies on humans and rodents have established that functional deterioration of CD4 T cells occurs with aging. We report in this study that approximately 70% of CD4(+)CD25(-) T cell preparations from individual 24-mo-old mice are hyporesponsive to in vitro stimulation with anti-CD3 Ab. The remaining 30% of CD4(+)CD25(-) T cell preparations showing the intermediate or normal responsiveness in the primary stimulation also exhibit the hyporesponsive properties after primary stimulation. Both of these hyporesponsive aged CD4(+)CD25(-) T cells could inhibit the proliferation of cocultured CD4(+)CD25(-) T cells from young mice, like CD4(+)CD25(+) T cells, which have recently been demonstrated as an immune regulator in young mice. Another experiment revealed that hyporesponsive aged CD4(+)CD25(-) T cells arrest the cell division of cocultured young CD4(+)CD25(-) T cells. The suppressive activity observed in aged CD4(+)CD25(-) T cells is aging-dependent, not mediated by humoral factors, cell-contact dependent, and broken by the addition of IL-2 or anti-GITR Ab, but not by anti-CTLA-4 Ab. These studies show that aging not only leads to a decline in the ability to mount CD4(+)CD25(-) T cell responses, but at the same time, also renders these aged CD4(+)CD25(-) T cells suppressive. |
