| First Author | Kassed CA | Year | 2003 |
| Journal | Brain Res Mol Brain Res | Volume | 110 |
| Issue | 1 | Pages | 152-7 |
| PubMed ID | 12573544 | Mgi Jnum | J:81874 |
| Mgi Id | MGI:2450180 | Doi | 10.1016/s0169-328x(02)00658-7 |
| Citation | Kassed CA, et al. (2003) Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-kappaB p50 in hippocampal neurons after injury. Brain Res Mol Brain Res 110(1):152-7 |
| abstractText | Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-kappaB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury. |
