| First Author | Banerjee H | Year | 2003 |
| Journal | Plasmid | Volume | 49 |
| Issue | 1 | Pages | 30-3 |
| PubMed ID | 12583998 | Mgi Jnum | J:81927 |
| Mgi Id | MGI:2450354 | Doi | 10.1016/s0147-619x(02)00106-3 |
| Citation | Banerjee H, et al. (2003) Identification of a mouse orthologue of the CED-6 gene of Caenorhabditis elegans. Plasmid 49(1):30-3 |
| abstractText | The rapid engulfment of apoptotic cells is a specialized innate immune response used by organisms to remove apoptotic cells. In mammals, several receptors that recognize apoptotic cells have been identified. Previous analysis of the engulfment gene ced-6 in Caenorhabditis elegans (C. elegans) has suggested that CED-6 is an adapter protein that participates in signal transduction pathway that mediates the specific recognition and engulfment of apoptotic cells. Here, we describe our isolation and partial characterization of a mouse cDNA, which is like an orthologue of C. elegans CED-6. PCR screening of mouse cDNA pool with primers designed from the C. elegans CED-6 cDNA sequence resulted in about 300bp PCR product which was partially sequenced and then screened to a mouse full-length cDNA library. Thus in this study we report the identification of a novel C. elegans CED-6-like orthologue in mouse, which has probable apoptotic like function. |
