| First Author | Fox N | Year | 1993 |
| Journal | FEBS Lett | Volume | 323 |
| Issue | 1-2 | Pages | 40-4 |
| PubMed ID | 8495745 | Mgi Jnum | J:83219 |
| Mgi Id | MGI:2658779 | Doi | 10.1016/0014-5793(93)81444-5 |
| Citation | Fox N, et al. (1993) Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM). FEBS Lett 323(1-2):40-4 |
| abstractText | To model islet amyloidogenesis in NIDDM and explore the glucoregulatory role of islet amyloid polypeptide (IAPP), we have created transgenic mice containing a rat insulin-I promoter-human IAPP fusion gene. Expression of human IAPP was localized to the islets of Langerhans, anterior pituitary and brain in transgenic animals; blood IAPP levels were elevated 5-fold while fasting glucose levels remained normal. Amyloid deposits have not been detected in transgenic islets suggesting that other co-existing abnormalities in NIDDM may be required for the formation of islet amyloid. These animals provide a unique model for exploring this hypothesis and other proposed functions of IAPP. |
