| First Author | Seward RJ | Year | 2003 |
| Journal | Mol Immunol | Volume | 39 |
| Issue | 16 | Pages | 983-93 |
| PubMed ID | 12749905 | Mgi Jnum | J:83490 |
| Mgi Id | MGI:2662087 | Doi | 10.1016/s0161-5890(03)00047-6 |
| Citation | Seward RJ, et al. (2003) Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis. Mol Immunol 39(16):983-93 |
| abstractText | Bim is a pro-apoptotic member of the Bcl-2 protein family. Bim has three isoforms, EL, L, and S, of which the EL form is the least cytotoxic. We show here that Bim is serine phosphorylated in lymphocytes, predominantly on the EL form. Withdrawal of IL-2 from IL-2-dependent T lymphocytes or culture of thymocytes leads to reduced Bim phosphorylation and apoptosis induction. This decrease in Bim phosphorylation occurs when most cells in culture are still viable, indicating that reduction of Bim phosphorylation may be an early event in apoptosis signaling of lymphocytes. |
